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Ukr. Bioorg. Acta 2020, Vol. 15, N1, 47-52.


The mathematical description of dopamine electrochemical oxidation, accompanied by its chemical and electrochemical polymerization

Volodymyr V. Tkach1,2, Marta V. Kushnir1, Yana G. Ivanushko3, Svitlana M. Lukanova1, Silvio C. de Oliveira2, Petro I. Yagodynets1

1 Yuriy Fedkovich Chernivtsi National University, 2 Kotsiubynsky St., Chernivtsi, 58012, Ukraine
tel.: +380-50-640-0359; e-mail: nightwatcher2401@gmail.com
2 Universidade Federal de Mato Grosso do Sul, Ave. Sen. Felinto. Muller, 1555, C/P. 549, 79074-460, Campo Grande, MS, Brazil
3 Bukovinian State Medical University, 9 Teatralna Sq., Chernivtsi, 58000, Ukraine

The electrooxidation of dopamine is accompanied by its chemical and electrochemical polymerization, and in which either the monomer or the polymer may be oxidized to the respective quinonic form, was investigated from the theoretical point of view. Dopamine is one of the important neurotransmitters in human and mammal organisms. It is a precursor to epinephrine, which influences the cardiovascular, hormonal and renal functions. Its lack causes diseases like Parkinson, therefore, dopamine has been used as a drug for their treatment. On the other hand, its excess stimulates the sympatic nervous system yielding the metabolic disorders and even schizophrenia. Thus, the development of the rapid and accurate method for its concentration measurement is very important. Dopamine is very popular analyte in electroanalytical systems. The modified electrodes for its determinations have been developed by many researchers. Dopamine is widely used as a monomer for synthesis of a conducting polymer Ė polydopamine, whis is used as electrodesí modifier in capacitors and in anticorrosive coatings. The electropolymerization of dopamine into polydopamine proceeds along with its traditional quinone-hydroquinonic oxidation. Both processes give their impact to the electrochemical behavior of dopamine during its electropolymerization. The mechanismís complexity is also responsible for the electrochemical instabilities during electro-oxidation. In order to understand these instabilities itís necessary to develop the mathematical model that is capable to describe the behavior of the system. It also helps us to esteem the influence of the electrochemical instabilities, by which it may be accompanied. The goal of this work is to describe an electrochemical oxidation and polymerization of dopamine that will provide an important connection between the electrochemical detection of biologically active compounds and their electropolymerization for electrode modification.

dopamine; polydopamine; electrooxidation; electropolymerization; mathematical model.

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1. Fellous, J-M.; Suri, R. E. The Roles of Dopamine. In The Handbook of Brain Theory and Neural Networks, 2nd Ed.; Arbib, M. A., Ed.; MIT Press: Cambridge, MA, 2003; pp 361-365.
2. Benes, F. M. Carlsson and the discovery of dopamine. Trends in Pharmacol. Sci. 2001, 22, 46-47.
3. Dopamine, CID=681. In PubChem Database. National Center for Biotechnology Information [Internet]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/dopamine#section=Use-and-Manufacturing (accessed on April 03, 2020).
4. Dopamine, GtoPdb Ligand ID: 940. In IUPHAR Database (IUPHAR-DB) via the Guide to PHARMACOLOGY website [Internet]. Available from: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=biology&ligandId=940 (accessed on April 03, 2020).
5. Kirshner, N.; Goodall, Mc. C. The formation of adrenaline from noradrenaline. Biochim. Biophys. Acta 1957, 24, 658-659.
6. Triarhou, L. C. Dopamine and Parkinson's Disease. In Madame Curie Bioscience Database [Internet]. (Austin, TX: Landes Bioscience;) 2000-2013. Available from: https://www.ncbi.nlm.nih.gov/books/NBK6271/ (accessed on April 03, 2020).
7. Seeman, P. Glutamate and dopamine components in schizophrenia. J. Psychiatry Neurosci. 2009, 34, 143-149.
8. Costa, M. de L.; Loria, A.; Marchetti, M.; Balaszczuk, A. M.; Arranz, C. T. Effects of dopamine and nitric oxide on arterial pressure and renal function in volume expansion. Clin. Exp. Pharmacol. Physiol. 2002, 29, 772-776.
9. Sasso, L.; Heiskanen, A.; Diazzi, F.; Dimaki, M.; Castillo, J.; Vergani, M.; Landini, E.; Raiteri, R.; Ferrari, G.; Carminati, M.; Sampietro, M.; Svendsen, W. E.; Emneus, J. Doped Overoxidized Polypyrrole Microelectrodes as Sensors for the Detection of Dopamine Released from Cell Populations. Analyst 2013, 138, 3651-3659.
10. Scarpetta, A.; Marino, K.; Bolanos et al. Determination of hydroquinone using a glassy carbon electrode modified with chitosan, multi-wall carbon nano-tubes and ionic liquid. Possible use as sensor. Rev. Colomb. Cienc. Quim. Farm. 2015, 44, 311-321. (In Spanish).
11. Ankireddy, R.; Kim, J. Selective detection of dopamine in the presence of ascorbic aced via fluorescence quenching of InP/ZnS quantum dots. Int. J. Nanomed. 2015, 10, 113-119.
12. Fayemi, O. F., Adekunle, A. S., Ebenso, E. E. Metal oxide nanoparticles/multi-walled carbon nanotube nanocomposite modified electrode for the detection of dopamine: comparative electrochemical study. J. Biosens. Bioelectr. 2015, 6, 190-204.
13. Peik-See, T.; Pandikumar, A.; Nay-Ming, H.; Hong-Ngee, L.; Sulaiman, Y. Simultaneous electrochemical detection of dopamine and ascorbic acid using an iron oxide/reduced grapheme oxide modified glassy carbon electrode. Sensors 2014, 14, 15227-15243.
14. Vishwanatha, C. C.; Swamy, B. E. K.; Pai, K. V. Electrochemical Studies of Dopamine, Ascorbic Acid and Uric Acid at Lignin Modified Carbon Paste Electrode by Cyclic Voltammetric. J. Anal. Bioanal. Tech. 2015, 6, 237-242.
15. Raoof, J. B.; Kiani, A.; Ojani, R.; Valliolahi, R. Electrochemical determination of dopamine using banana-MWCNTs modified carbon paste electrode. Anal. Bioanal. Electrochem. 2011, 3, 59-66.
16. Ojani, R.; Rahimi, V.; Raoof, J. A new voltammetric sensor for hydrazine based on michael addition reaction using 1-amino-2-naphtol-4-sulfonic acid. J. Chin. Chem. Soc. 2015, 62, 90-96.
17. Khajvand, T.; Ojani, R.; Raoof, J. B. Tetrachloro-ortho-Benzoquinone as Catalyst for Electrocatalytic Oxidation of Sulfite in Acidic Media and its Analytical Application. Anal. Bioanal. Electrochem. 2014, 6, 501-514.
18. Wang, J. L.; Li, B. C.; Li, Z. J. et. al. Electropolymerization of dopamine for surface modification of complex-shaped cardiovascular stents. Biomaterials 2014, 35, 7679-7689.
19. Mahantesha, K. R.; Swamy, B. E. K.; Pai, K. V. Poly (alizarin) Modified glassy carbon electrode for the electrochemical investigation of omeprazole: A voltammetric study. Anal. Bioanal. Electrochem. 2014, 6, 234-244.
20. Das, I., Agrawal, N.R.; Ansari, S. A.; Gupta, S. K. Pattern formation and oscillatory polymerization of thiophene. Ind. J. Chem. 2008, 47A, 1798-1803.
21. Tkach, V.; Nechyporuk, V.; Yagodynets, P. Electropolymerization of heterocyclic compounds. Mathematical models. Cien. Tecn. Mat. 2012, 24, 54-58 (In Portuguese).
22. Krische, B.; Zagorska, M. The polythiophene paradox. Synth. Met. 1989, 28, 263-268.
23. Tkach, V.; Nechyporuk, V.; Yagodynets, P. Description matematica de la sintesis electroquimica de polimeros conductors en la presencia de surfactants. Avances en. Quimica. 2013, 8, 9-15 (In Spanish).
24. Li, Y.; Chen, Sh. M. The Electrochemical Properties of Acetaminophen on Bare Glassy Carbon Electrode. Int. J. Electrochem. Sci. 2012, 7, 2175-2187.
25. Vishwanath, C. C.; Swamy, B. E. K. Electrochemical studies of paracetamol at Poly (Aniline Blue) modified carbon paste electrode: A voltammetric study. Anal. Bioanal. Electrochem. 2014, 6, 573-582.
26. Tkach, B. Kumara-Swamy, R. Ojani et al. Paracetamol behavior during the electrocatalytic oxidation of poly (aniline blue) and its mathematical description. Rev. Colomb. Cienc. Quim. Farm. 2015, 44, 148-161 (In Portuguese).

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