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Ukr. Bioorg. Acta 2020, Vol. 15, N2, 3-12.

 Features of the synthesis and biological evaluation of
3-(carboxyphenyl)chromones

Olga V. Shablykina, Viktoriia S. Moskvina*, Volodymyr P. Khilya

V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine.
tel.: +380-44-239-3342; e-mail: v.moskvina@gmail.com

ABSTRACT
Flavonoids and their derivatives have historically been a source of therapeutic agents. Every year, more and more data is published on new flavonoid compounds (both isolated from natural sources and synthesized) and their innumerable physiological and pharmacological activities. This review presents synthetic routes towards 3-(carboxyphenyl)chromones and their biological activity as published in both journal and patent literature. We have focused specifically on the 3-(carboxyphenyl)chromones, since there is a lot of data on the methods of synthesis and biological activity of 2(3)-substituted and 2,3-disubstituted chromones, but literature data on isoflavones containing a carboxyl, ester, or amide group in ring B is scarce and fragmentary. The presented generalization of synthetic strategies and biological activity of 3-(carboxyphenyl)chromone derivatives demonstrates that this class of compounds can be targeted for the discovery of new drugs and can be readily prepared owing to recent advances in synthetic organic and medicinal chemistry.

KEYWORDS
chromones, isoflavones, biological activity, synthesis

Full text: (PDF, in English)

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