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Ukr. Bioorg. Acta 2021, Vol. 16, N1, 10-17.

New 4-iminohydantoin sulfamide derivatives with antiviral and anticancer activity

Yurii Eu. Kornii1, Oleh V. Shablykin1, Olga V. Shablykina1,2*, Volodymyr S. Brovarets1

1V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine
2Taras Shevchenko National University of Kyiv, 60 Volodymyrska St., Kyiv, 01601, Ukraine
tel.: +380-66-167-9812; e-mail: shablykina@ukr.net

A number of sulfamides were obtained by reaction of (5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride with anilines, benzylamines, Boc-protected piperazine, methylalylamine, and amino acids methyl esters with primary and secondary amino group. The antiviral and anticancer activity of new derivatives was evaluated. The most effective compounds against Human cytomegalovirus were sulfamides based on anisidine (1b), N-Boc-piperazine (1h), and the derivatives 1n,o with fragments of nipecotic and azetidine-3-carboxylic acids, respectively. Anticancer activity was most significant for sulfamides based on p-methoxybenzylamine (compound 1d), benzylmethylamine (compound 1f), and allylmethylamine (compound 1g).

hydantoins; sulfamides; antiviral activity; anticancer activity.

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