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Ukr. Bioorg. Acta 2021, Vol. 16, N1, 18-24.

Synthesis of novel pyrazoline-thiazolidin-4-one hybrids and evaluation their biological activity

Serhii M. Holota1,2*

1Danylo Halytsky Lviv National Medical University, 69 Pekarska St., Lviv, 79010, Ukraine
2Lesya Ukrainka Volyn National University, 13 Voli Ave., Lutsk, 43025, Ukraine

tel.: +380-97-226-0066; e-mail: golota_serg@yahoo.com

In the present work, the synthesis of pyrazoline-thiazolidin-4-one hybrids and their pharmacological properties are described. The structure of compounds is characterized using
1H, 13C NMR, and LC-MS spectra. The antioxidant (DPPH assay), antimicrobial (Gram-positive bacterium Lactobacillus plantarum, Gram-negative bacterium Escherichia coli, and yeasts Candida albicans, MIC determination), redox (cyclic voltammetry) as well as herbicidal activity (against grass species Agrostis stolonifera) of compounds have been studied. All derivatives have demonstrated radical scavenging activity with IC50 values in the range from 4.67-7.12 mM in the DPPH test. The tested compounds presented very low antimicrobial and herbicidal activity and no redox peaks were observed in the cyclic voltammetry studies.

pyrazoline-thiazolidin-4-ones hybrids; DPPH assay; antimicrobial/herbicidal activity; cyclic voltammetry.

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